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Inspired by advanced dermatological research, this growth factor anti-aging serum is engineered to support the appearance of healthier, more youthful-looking skin.
Packaged in a dual-chamber pump dispenser
Advanced blend of growth factor and peptide ingredients designed to help address visible signs of aging.
Combination of botanicals and marine extracts to support skin renewal and resilience.
Net Weight: 1 oz. (28.4g)
This product is not endorsed or associated with TNS Advanced+ Serum or its manufacturer Allergan, Inc. / SkinMedica.
The Active Pro Serum contains all 32 ingredients listed in SkinMedica® TNS Advanced+ Serum™, based on a comparison of publicly available INCI labels.
Ingredient comparison does not reflect ingredient concentrations, formulation process, performance, or product equivalence.
Clean and pat face dry.
Dispense 1/2–1 pump from each chamber and blend together.
Apply the serum evenly to your face.
A fibroblast-derived growth factor that helps support the appearance of smoother texture, visible firmness, and more youthful-looking skin.
An anti-aging peptide that supports the look of firmness and softened fine lines.
A postbiotic skin care ingredient that helps support a healthier-looking skin barrier and more balanced-looking skin.
A nutrient-dense microalgae that helps support a refreshed, radiant, more youthful-looking complexion.
Aqua/Water/Eau, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin
Our Human Fibroblast Conditioned Media is sourced from a U.S.-based biotechnology partner that specializes in human cell culture and regenerative research technologies. The conditioned media is derived from human fibroblast stem cells originally sourced from ethically obtained umbilical tissue that is voluntarily donated postpartum and not derived from aborted fetal tissue.
It is naturally rich in extracellular vesicles, including exosomes, growth factors, and signaling proteins that support skin renewal and cellular communication. Our conditioned media contains naturally occurring extracellular vesicles in the 60–90 nm range at concentrations on the order of approximately 10¹² to 10¹³ (1 to 10 trillion) particles per milliliter, making it a robust source of bioactive components for cosmetic formulations.
Our conditioned media has undergone comprehensive evaluation for cosmetic use and was selected based on stringent quality, safety, and performance benchmarks. We maintain strict standards for ethical sourcing and scientific validation.
Because great skin shouldn’t cost a fortune.
Active Pro Serum is for anyone looking to address visible signs of aging, including fine lines, wrinkles, uneven texture, dullness, and loss of firmness.
Some customers may notice minor visible improvements within 1–2 weeks. More noticeable results may appear around 3–4 weeks. The most visible results are typically seen after 5–6 weeks of daily use.
Results vary by skin type, routine, and consistency of use.
Active Pro Serum contains all 32 ingredients listed in SkinMedica® TNS Advanced+ Serum™, based on a comparison of publicly available INCI labels.
This does not reflect ingredient concentrations, manufacturing process, ingredient sourcing, delivery system, clinical testing, or product performance.
Made in USA of US and/or imported ingredients.
Compliant with strict industry standards for manufacturing and safety.
No animal testing is performed on any of our finished products.
Your satisfaction matters. If you’re not happy with your experience for any reason, return your product within 30 days for a refund.
Overall rating: 4.8 / 5 from 526 reviews.
I am a long time Skinmedica TNS user. I bought this while I still had TNS left to do a morning / evening rotation between the two. It feels the same, has the same consistency and I truly can't tell the difference. The one concern has been I've struggled a bit with the pump, but that has since been re-designed since I last purchased. I will most definitely be a return customer, in fact, I'm back now to purchase more!
I literally can’t tell the difference in results with Active Pro Serum versus SkinMedica TNS advanced serum! This product is so much more affordable and less product waste! So glad I discovered it! ❤️🙌🏽
I have been a loyal customer of the skinmedica TNS serum for 3 years. I was looking for something that would not be so bulky when traveling due to packaging. Happened to find the generic version and was pleasently suprised with the quality. Generic product is 75% cheaper. No going back
The Skincare generic brand is very similar to the Skinmedica TNS serum. I really enjoy using it.
Ingredients are exactly the same, the order of ingredients are exactly the same, the smell is exactly the same, and as you can see on the video the texture, color, and appearance is exactly the same as Skinmedica TNS. I’ll be buying this product from now on.
I absolutely love this product. I love it when you guys throw a little discount and I just want to stock up. I don’t want to run out amazing product same exact results like I’m just so happy to be able to get this at a more economical price than the Skin Medica TNS.
I have been using this for about a month now. I also have the TNS and was using that before. I know my skin is moisturized just as well as the TNS and it feels the same on my skin. I have been using it twice a day, but since it’s only been a month I’m not expecting amazing results yet. I plan on using this for at least 6 months to see results. I have deep forehead lines and a crease between my eyes I’d like to see some improvement on. Also wrinkles and darkness under my eyes, basically the difficult areas to see results from. I like the texture a lot, I love that it’s fragrance free as well. I’m purchasing a 3 pack as soon as I finish this review.
I’m 38 and had been using the TNS serum for about a year and it made the best difference in my skin. I recently heard about this one and I can tell no difference between it and the expensive one. This one smells and feels the same with the same great results. Keeps my skin feeling firm and looking glowy. I have extremely sensitive and reactive skin and no issues here! SO glad there is a MUCH more affordable option
Actual TNS user here. Tried this and I’m honestly impressed. Feels amazing on my skin and absorbs real well. I actually like that it smells like the original. Great product for the price
The photo I enclosed is a closeup of an area that is problematic for many women my age (closing in on 74 in the fall). I get many comments (even from the PA at my dermatologist) about how good my skin looks (I know they kindly keep “for your age” to themselves). I’ve used the original SkinMedica TNS product for many years but often take a break due to cost. It’s early, but the Active Pro Serum formula seems to behave identically to the TNS. Would love to see Skincare Generics up the formula to include Exosomes, which SkinMedica has not done…yet. In the meantime this is a winner!
I struggle with fine lines due to sun exposure, this product is the only one that seems to actually improve them. Dries quickly and is an easy second to last step before applying sunscreen.
I have been using for several months now and definitely see an improvement in fine lines, wrinkles and texture.
Like the Pro Serum very much. I use it every night
This is my 3rd bottle…love how silky it is. A little goes a long way so I’m able to make it last a bit longer.
Really enjoying this serum and have been using for a few months, goes on smoothly and sits well under sunscreen and make up!!!
The Skin Medica serum and this active pro serum from skin care generics is exactly the same. I’ve used the high-end one won’t even say how much I spent on that till this came along now I no longer buy the high-end when you can buy this and it’s just the same no fancy packaging but same amazing product give it a try. You will not regret it. I always keep backstock because I don’t want to run out of it because it sells out so often lol because that’s how good it is.
This is the absolute best serum and great price too!! 💕
I really like this. It has the exact same feel and smell of the other product. I love that they changed the delivery system to the two pump method. Works every time now.
I have owned the brand name TNS serum and yes it worked great, but at a ridiculously high price point. This Active Pro Serum works just as well as the TNS serum for me and at a fraction of the cost. I will continue buying the Active Pro Serum.
I bought this looking for an affordable alternative to the SkinMedica TNS Advanced+ Serum recommended by my aesthetic nurse practitioner. I was skeptical when I first read about this product on a blog, but given the price, I figured it was worth a shot. As you can see from my photos, it has made a massive difference in my skin! I am incredibly happy with this product and highly recommend it if you want high-end results on a budget.
works better than the original !
I really love this product. I don’t have any sensitivity around my eyes which is wonderful. I also see a tighter lifted jaw line. What I have noticed that I am not seeing in photos is that it is helping shrink a skin bump that I have had for over a year. I’m very pleased! Thank you Skincare Generics. I’ll post my one month mark in two weeks. This is my 2 week mark.
Love this product, make my face tight and supple
I love it! I’ve only been using it a few weeks and can already see a difference in my skin.
The dispenser could use some upgrading. The clear serum doesn't come out consistently. There is also a very slight fishy odor. Otherwise it feels the same. Hope this works!
Love the feel of this and love the price! Used the original but was out of my price range for long-term use. So excited to be able to try something that’s such a close approximation!
Excellent product
Great product
Love it) It’s amazing.
Repeat purchase! This serum is great and my skin loves it!! The only thing I was missing in my routine was growth factors- would highly recommend!
I absolutely love this product! I am an ingredient snob, and try many, many products for my dry and aging skin. I have learned through much testing that you don't have to spend hundreds of dollars to get quality skincare, but that skincare at this pricepoint was never really available till now. This leaves my skin juicy and bouncy and plays well with any moisturizer or sunscreen I put on top of it. That is my ultimate goal and I am so grateful that not only does it work great but is very affordable for me. Thank you to the makers of this beautiful serum!🙏😊
The glow is phenomenal! I have sensitive skin and almost everything has an initial stinging to it when I apply it. This does not sting. I like that the serums are separated as to not jeopardize the integrity of the ingredients. Most of all, I like the price! I’ve been searching for probably around 4 months for a dupe to the $$$ TNS. I never expected to find an exact ingredient dupe. I’ve not been using this long enough to see skin changes but I’m excited to see what happens.
Can’t put my finger on what it’s done exactly, but my skin looks better. My skin is glowing and I receive regular compliments. I’ve been using .25 Tretinoin for a year and this is the only new thing I’ve changed.
The formulation is so easy to use and I have had no skin irritation at all. I use it about an hour before my Tretinoin.
I noticed within the first week the fine lines around my mouth were less and my skin was smoother. My makeup goes on and even stays smooth much longer throughout the day. This product has been a life changer for me.
So far, it’s been 2 weeks and I’ve been using only at night but I can definitely see and feel a difference. My skin is much more plump. Will continue using and report back after a month and then with continued use.!
Found this dupe on a YouTube podcaster that I love. And have been using it ever since.
I am on my second bottle of this and have 2 back ups waiting. I never tried the original serum BUT I absolutely love this. I am seeing a difference in my 55 year old skin. My skin is smoother, clearer and pores and lines are minimized.
I’ve been using this product for a few months and I have definitely seen a difference in my skin texture and skin tone. My skin does not look as blotchy anymore and it looks and feels smoother.. I purchased these two products together in a set and it seems to be a great combination.. The cleanser does not dry my skin at all. I will re-purchase.
I’ve used TNS serum for a couple of years, I love it but it’s very expensive.To me Skincare Generics is the exact formula. It’s fantastic.
Reviews reflect the personal opinions of customers and are not claims made by Skincare Generics. References to "dupes" or similarity are individual perceptions and do not imply product equivalence.
What exactly is ACTIVE PRO SERUM?
ACTIVE PRO SERUM is a growth factor–derived serum formulated to help improve the appearance of visible signs of aging skin, including fine lines and wrinkles. It features a dual-chamber pump with complementary blends, advanced growth factors, peptides, antioxidants, botanicals marine extracts, and skin-boosting nutrients to improve the appearance of skin texture and overall radiance.
ACTIVE PRO SERUM contains human fibroblast conditioned media sourced from a leading, FDA-registered, U.S. biotechnology manufacturer that produces cell-derived ingredients used across biotechnology and premium skincare applications. The conditioned media is derived from ethically donated, postpartum umbilical tissue and produced in compliance with U.S. regulatory standards.
Packaged in a dual-chamber pump dispenser:
Chamber 1: Advanced blend of growth factor and peptide ingredients designed to help address visible signs of aging.
Chamber 2: Combination of botanicals and marine extracts to support skin renewal and resilience.
• SkinSkool - Match Excellence Reward 2026
What ingredients are in ACTIVE PRO SERUM?
Aqua/Water/Eau, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin
Our Human Fibroblast Conditioned Media is sourced from a U.S. based biotechnology partner that specializes in human cell culture and regenerative research technologies. The conditioned media is derived from human fibroblast stem cells originally sourced from ethically obtained umbilical tissue that is voluntarily donated postpartum and not derived from aborted fetal tissue.
It is naturally rich in extracellular vesicles (including exosomes), growth factors, and signaling proteins that support skin renewal and cellular communication. Our conditioned media contains naturally occurring extracellular vesicles in the 60–90 nm range at concentrations on the order of approximately 10¹² to 10¹³ (1 to 10 trillion) particles per milliliter, making it a robust source of bioactive components for cosmetic formulations.
Our conditioned media has undergone comprehensive evaluation for cosmetic use and was selected based on stringent quality, safety, and performance benchmarks. We maintain strict standards for ethical sourcing and scientific validation.
Is ACTIVE PRO SERUM exactly the same as the competitor listed on the packaging?
Our product is not the same as the competitor. However, our formulations are developed by reviewing publicly available ingredient lists and selecting similar categories of ingredients where appropriate. Each product is independently formulated and manufactured.
Our products are also formulated with careful attention to texture and sensory experience. More importantly, we are always looking to improve upon our current formulations to deliver a luxury skincare experience.
Products are not affiliated with, endorsed by, or identical to any luxury brand.
How do the ingredients in ACTIVE PRO SERUM match with the competitor?
Each Skincare Generics product is independently formulated using similar categories of ingredients where appropriate. Ingredient comparisons are based solely on publicly available information and do not reflect formulation equivalence, performance equivalence, or clinical similarity.
For transparency, consumers may review publicly available ingredient lists on brand websites to compare ingredients.
How does the price of ACTIVE PRO SERUM compare with the competitor?
You can view a side-by-side, comparison of ACTIVE PRO SERUM's price vs. our competitor's price under the "Compare Prices" tab in the product description section.
How do "dupe" websites such as SkinSkool and SkinSort rate ACTIVE PRO SERUM vs. the competitor?
Here is ACTIVE PRO SERUM's rating on the different "dupe" websites:
• SkinSkool’s #1 Rated Match
• SkinSort’s #1 Rated Dupe
Ratings and terminology used by third-party websites reflect their independent criteria and do not imply equivalence.
Are there any published articles about ACTIVE PRO SERUM?
• SkinSkool - A New Serum Launch That Mirrors SkinMedica’s TNS Advanced+ At 83% Less
Editorial and comparative language, product classifications, and descriptions in third-party articles reflect the authors’ independent opinions and do not imply equivalence.
Are your skincare products considered clean?
While there is no industry-wide definition for “clean beauty,” major retailers such as Sephora and Ulta have established their own standards and guidelines. These typically involve excluding certain ingredients considered potentially harmful or questionable, such as sulfates, parabens, phthalates, and synthetic fragrances.
As we review publicly available ingredient lists when developing our products, some formulations may align with certain retailer “clean” standards, while others may contain ingredients that fall outside these guidelines, such as fragrance.
We encourage you to review each ingredient list individually to determine what aligns with your personal preferences and definition of “clean.”
How long will it take to receive my order?
It takes 1 - 2 business days to fulfill your order. Orders placed by 12pm CT, Monday through Friday, ship the same day. Orders received after the cutoff or on weekends will be processed the following business day.
Is international shipping available?
No, Skincare Generics does not currently offer direct international shipping.
Some customers choose to use third-party package forwarding services that provide a U.S. shipping address and then forward the package internationally, such as MyUS, Shipito, Stackry, Planet Express, and forward2me. These services are independent third parties and are not affiliated with or endorsed by Skincare Generics.
Once an order is delivered to the U.S. address entered at checkout, Skincare Generics is no longer responsible for the shipment or for any issues that arise afterward, including delays, loss, damage, customs issues, duties, taxes, fees, or forwarding errors. Refunds, replacements, and other remedies under our policies do not apply to issues arising after delivery to the forwarding address.
How do I manage or edit my subscription (delivery frequency, items, address, etc.)?
Here's how to log into your account and edit or manage your subscription (delivery frequency, items, address, etc.):
1) Log into your account
On Desktop (computer)
On Mobile (phone)
2) Change your subscription delivery frequency
If you don't see the "Frequency / Schedule" option
Sometimes certain settings don't allow self-service frequency changes. If you don't see that option, contact support at skincaregenerics.com/pages/contact and include:
...and we'll help update it for you.
What is your return policy?
We have a 30-day return no questions asked return policy, which means you have 30 days after receiving your item to request a return for any reason. Just email Customer Support and we will initiate a return or exchange.
Overall rating: 4.8 / 5 from 526 reviews.
I am a long time Skinmedica TNS user. I bought this while I still had TNS left to do a morning / evening rotation between the two. It feels the same, has the same consistency and I truly can't tell the difference. The one concern has been I've struggled a bit with the pump, but that has since been re-designed since I last purchased. I will most definitely be a return customer, in fact, I'm back now to purchase more!
I literally can’t tell the difference in results with Active Pro Serum versus SkinMedica TNS advanced serum! This product is so much more affordable and less product waste! So glad I discovered it! ❤️🙌🏽
I have been a loyal customer of the skinmedica TNS serum for 3 years. I was looking for something that would not be so bulky when traveling due to packaging. Happened to find the generic version and was pleasently suprised with the quality. Generic product is 75% cheaper. No going back
The Skincare generic brand is very similar to the Skinmedica TNS serum. I really enjoy using it.
Ingredients are exactly the same, the order of ingredients are exactly the same, the smell is exactly the same, and as you can see on the video the texture, color, and appearance is exactly the same as Skinmedica TNS. I’ll be buying this product from now on.
I absolutely love this product. I love it when you guys throw a little discount and I just want to stock up. I don’t want to run out amazing product same exact results like I’m just so happy to be able to get this at a more economical price than the Skin Medica TNS.
I have been using this for about a month now. I also have the TNS and was using that before. I know my skin is moisturized just as well as the TNS and it feels the same on my skin. I have been using it twice a day, but since it’s only been a month I’m not expecting amazing results yet. I plan on using this for at least 6 months to see results. I have deep forehead lines and a crease between my eyes I’d like to see some improvement on. Also wrinkles and darkness under my eyes, basically the difficult areas to see results from. I like the texture a lot, I love that it’s fragrance free as well. I’m purchasing a 3 pack as soon as I finish this review.
I’m 38 and had been using the TNS serum for about a year and it made the best difference in my skin. I recently heard about this one and I can tell no difference between it and the expensive one. This one smells and feels the same with the same great results. Keeps my skin feeling firm and looking glowy. I have extremely sensitive and reactive skin and no issues here! SO glad there is a MUCH more affordable option
Actual TNS user here. Tried this and I’m honestly impressed. Feels amazing on my skin and absorbs real well. I actually like that it smells like the original. Great product for the price
The photo I enclosed is a closeup of an area that is problematic for many women my age (closing in on 74 in the fall). I get many comments (even from the PA at my dermatologist) about how good my skin looks (I know they kindly keep “for your age” to themselves). I’ve used the original SkinMedica TNS product for many years but often take a break due to cost. It’s early, but the Active Pro Serum formula seems to behave identically to the TNS. Would love to see Skincare Generics up the formula to include Exosomes, which SkinMedica has not done…yet. In the meantime this is a winner!
I struggle with fine lines due to sun exposure, this product is the only one that seems to actually improve them. Dries quickly and is an easy second to last step before applying sunscreen.
I have been using for several months now and definitely see an improvement in fine lines, wrinkles and texture.
Like the Pro Serum very much. I use it every night
This is my 3rd bottle…love how silky it is. A little goes a long way so I’m able to make it last a bit longer.
Really enjoying this serum and have been using for a few months, goes on smoothly and sits well under sunscreen and make up!!!
The Skin Medica serum and this active pro serum from skin care generics is exactly the same. I’ve used the high-end one won’t even say how much I spent on that till this came along now I no longer buy the high-end when you can buy this and it’s just the same no fancy packaging but same amazing product give it a try. You will not regret it. I always keep backstock because I don’t want to run out of it because it sells out so often lol because that’s how good it is.
This is the absolute best serum and great price too!! 💕
I really like this. It has the exact same feel and smell of the other product. I love that they changed the delivery system to the two pump method. Works every time now.
I have owned the brand name TNS serum and yes it worked great, but at a ridiculously high price point. This Active Pro Serum works just as well as the TNS serum for me and at a fraction of the cost. I will continue buying the Active Pro Serum.
I bought this looking for an affordable alternative to the SkinMedica TNS Advanced+ Serum recommended by my aesthetic nurse practitioner. I was skeptical when I first read about this product on a blog, but given the price, I figured it was worth a shot. As you can see from my photos, it has made a massive difference in my skin! I am incredibly happy with this product and highly recommend it if you want high-end results on a budget.
works better than the original !
I really love this product. I don’t have any sensitivity around my eyes which is wonderful. I also see a tighter lifted jaw line. What I have noticed that I am not seeing in photos is that it is helping shrink a skin bump that I have had for over a year. I’m very pleased! Thank you Skincare Generics. I’ll post my one month mark in two weeks. This is my 2 week mark.
Love this product, make my face tight and supple
I love it! I’ve only been using it a few weeks and can already see a difference in my skin.
The dispenser could use some upgrading. The clear serum doesn't come out consistently. There is also a very slight fishy odor. Otherwise it feels the same. Hope this works!
Love the feel of this and love the price! Used the original but was out of my price range for long-term use. So excited to be able to try something that’s such a close approximation!
Excellent product
Great product
Love it) It’s amazing.
Repeat purchase! This serum is great and my skin loves it!! The only thing I was missing in my routine was growth factors- would highly recommend!
I absolutely love this product! I am an ingredient snob, and try many, many products for my dry and aging skin. I have learned through much testing that you don't have to spend hundreds of dollars to get quality skincare, but that skincare at this pricepoint was never really available till now. This leaves my skin juicy and bouncy and plays well with any moisturizer or sunscreen I put on top of it. That is my ultimate goal and I am so grateful that not only does it work great but is very affordable for me. Thank you to the makers of this beautiful serum!🙏😊
The glow is phenomenal! I have sensitive skin and almost everything has an initial stinging to it when I apply it. This does not sting. I like that the serums are separated as to not jeopardize the integrity of the ingredients. Most of all, I like the price! I’ve been searching for probably around 4 months for a dupe to the $$$ TNS. I never expected to find an exact ingredient dupe. I’ve not been using this long enough to see skin changes but I’m excited to see what happens.
Can’t put my finger on what it’s done exactly, but my skin looks better. My skin is glowing and I receive regular compliments. I’ve been using .25 Tretinoin for a year and this is the only new thing I’ve changed.
The formulation is so easy to use and I have had no skin irritation at all. I use it about an hour before my Tretinoin.
I noticed within the first week the fine lines around my mouth were less and my skin was smoother. My makeup goes on and even stays smooth much longer throughout the day. This product has been a life changer for me.
So far, it’s been 2 weeks and I’ve been using only at night but I can definitely see and feel a difference. My skin is much more plump. Will continue using and report back after a month and then with continued use.!
Found this dupe on a YouTube podcaster that I love. And have been using it ever since.
I am on my second bottle of this and have 2 back ups waiting. I never tried the original serum BUT I absolutely love this. I am seeing a difference in my 55 year old skin. My skin is smoother, clearer and pores and lines are minimized.
I’ve been using this product for a few months and I have definitely seen a difference in my skin texture and skin tone. My skin does not look as blotchy anymore and it looks and feels smoother.. I purchased these two products together in a set and it seems to be a great combination.. The cleanser does not dry my skin at all. I will re-purchase.
I’ve used TNS serum for a couple of years, I love it but it’s very expensive.To me Skincare Generics is the exact formula. It’s fantastic.
