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ACTIVE PRO SERUM is an advanced serum formulated to address the appearance of wrinkles, fine lines and visible signs of aging. Compare to SkinMedica® TNS Advanced+ Serum™
This next-generation serum features complementary blends, including growth factor and peptide ingredients, along with botanicals and marine extracts. Each bottle contains over 1 trillion naturally occurring exosomes, helping support skin communication and renewal.
Packaged in a dual-chamber pump dispenser:
• Chamber 1: Advanced blend of growth factor and peptide ingredients designed to help address visible signs of aging.
• Chamber 2: Combination of botanicals and marine extracts to support skin renewal and resilience.
Net Weight 1 oz. (28.4g)
Cruelty Free and Made in USA of domestic and/or imported ingredients.
SkinSkool’s #1 Rated Match
SkinSort’s #1 Rated Dupe
This product is not endorsed or associated with TNS Advanced+ Serum or its manufacturer Allergan, Inc. / SkinMedica
Prices as of March 2026:
• TNS Advanced+ Serum (1 oz) -- $295.00
• Active Pro Serum (1 oz) -- $49.99 | 83% Less!
Active Pro Serum contains all 32 ingredients listed in SkinMedica TNS Advanced+ Serum, based on comparison of publicly available INCI labels. Does not reflect ingredient concentrations or performance.
Aqua/Water/Eau, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin
Our Human Fibroblast Conditioned Media is sourced from a U.S. based biotechnology partner that specializes in human cell culture and regenerative research technologies. The conditioned media is derived from human fibroblast stem cells originally sourced from ethically obtained umbilical tissue that is voluntarily donated postpartum and not derived from aborted fetal tissue.
It is naturally rich in extracellular vesicles (including exosomes), growth factors, and signaling proteins that support skin renewal and cellular communication. Our conditioned media contains naturally occurring extracellular vesicles in the 60–90 nm range at concentrations on the order of approximately 10¹² to 10¹³ (1 to 10 trillion) particles per milliliter, making it a robust source of bioactive components for cosmetic formulations.
Our conditioned media has undergone comprehensive evaluation for cosmetic use and was selected based on stringent quality, safety, and performance benchmarks. We maintain strict standards for ethical sourcing and scientific validation.
Directions:
1. Invert bottle and tap the bottom to help ensure serum is primed for proper dispensing.
2. Dispense about 1/2 to 1 pump from each chamber into hand.
3. Blend serum together and apply to the face, neck, and décolletage.
4. For best results, use ACTIVE PRO SERUM, twice daily, morning and evening, after cleansing and toning.
NOTE: If you experience dispensing issues from either of the nozzles, try removing the top pump assembly. Press in the center of the bottle above the logo and just below the connecting seam and carefully pull the top off at the same time without spilling product. Once removed, reattach, tap the bottom of the bottle a few times to prime the serum, and try to pump out the product again. This should clear any air bubbles or alignment issues, and alleviate the pump issue.
Precautions:
1. ACTIVE PRO SERUM is for external use only.
2. Avoid contact with eyes. Rinse thoroughly with water if contact with eyes occur.
3. If irritation occurs, discontinue use.
New Users:
A sensitivity test is recommended for those using ACTIVE PRO SERUM for the first time. Apply a small amount of product to a small area of clean, dry skin on the back of your hand. If any irritation or sensitivity develops, discontinue use immediately.
Your satisfaction matters. If you’re not happy with your experience for any reason, return your product within 30 days for a refund.
Enjoy free standard shipping on all orders over $60.
Compliant with strict industry standards for manufacturing and safety.
Made in USA of US and/or imported ingredients.
No animal testing is performed on any of our finished products.
Because great skin shouldn’t cost a fortune.
Overall rating: 4.8 / 5 from 623 reviews.
I am a long time Skinmedica TNS user. I bought this while I still had TNS left to do a morning / evening rotation between the two. It feels the same, has the same consistency and I truly can't tell the difference. The one concern has been I've struggled a bit with the pump, but that has since been re-designed since I last purchased. I will most definitely be a return customer, in fact, I'm back now to purchase more!
I literally can’t tell the difference in results with Active Pro Serum versus SkinMedica TNS advanced serum! This product is so much more affordable and less product waste! So glad I discovered it! ❤️🙌🏽
I have been a loyal customer of the skinmedica TNS serum for 3 years. I was looking for something that would not be so bulky when traveling due to packaging. Happened to find the generic version and was pleasently suprised with the quality. Generic product is 75% cheaper. No going back
The Skincare generic brand is very similar to the Skinmedica TNS serum. I really enjoy using it.
Ingredients are exactly the same, the order of ingredients are exactly the same, the smell is exactly the same, and as you can see on the video the texture, color, and appearance is exactly the same as Skinmedica TNS. I’ll be buying this product from now on.
I absolutely love this product. I love it when you guys throw a little discount and I just want to stock up. I don’t want to run out amazing product same exact results like I’m just so happy to be able to get this at a more economical price than the Skin Medica TNS.
I have been using this for about a month now. I also have the TNS and was using that before. I know my skin is moisturized just as well as the TNS and it feels the same on my skin. I have been using it twice a day, but since it’s only been a month I’m not expecting amazing results yet. I plan on using this for at least 6 months to see results. I have deep forehead lines and a crease between my eyes I’d like to see some improvement on. Also wrinkles and darkness under my eyes, basically the difficult areas to see results from. I like the texture a lot, I love that it’s fragrance free as well. I’m purchasing a 3 pack as soon as I finish this review.
I’m 38 and had been using the TNS serum for about a year and it made the best difference in my skin. I recently heard about this one and I can tell no difference between it and the expensive one. This one smells and feels the same with the same great results. Keeps my skin feeling firm and looking glowy. I have extremely sensitive and reactive skin and no issues here! SO glad there is a MUCH more affordable option
Actual TNS user here. Tried this and I’m honestly impressed. Feels amazing on my skin and absorbs real well. I actually like that it smells like the original. Great product for the price
The photo I enclosed is a closeup of an area that is problematic for many women my age (closing in on 74 in the fall). I get many comments (even from the PA at my dermatologist) about how good my skin looks (I know they kindly keep “for your age” to themselves). I’ve used the original SkinMedica TNS product for many years but often take a break due to cost. It’s early, but the Active Pro Serum formula seems to behave identically to the TNS. Would love to see Skincare Generics up the formula to include Exosomes, which SkinMedica has not done…yet. In the meantime this is a winner!
My current active serum costs me $140. And I don't use a vitamin C because it bothers my skin. This active serum is a fraction of the cost and no joke, I see results in 2 weeks of using it! And this vitamin C has not bothered my skin whatsoever! Definitely ordering again and have already recommended to friends.
After getting through two bottles of the Active Pro Serum my skin has never felt better. This is my new go to!! I’m so happy to get this for such a good price. I’m trying all your products next!
Absolutely love this and will be purchasing it again!!!!
Great product! I’m on my 4th bottle. Great customer service as well. Thank you!
It’s great
Love! Just like the tns! I’ve use the other in the past and can say that it smells and feels the exact same. I feel like results are the same too. Purchasing my second bottle.
Absolutely addicted - top quality, fabulous price. My skin jadores it 💖
I used the TNS serum for several months , loved the product but could non longer afford it. I tried this Active Pro-Serum from Skincare Generics and I can honestly say it is identical and has continued to do wonders for my skin!
Great! Wonderful product
I love this product! It does wonders for my skin!
Love the products. Feels, performs and smells like the "original" music higher priced versions. Glad I found these products
Skincare Generics is a wonderful company. Their products are moisturizing and feel great on my skin! I would highly recommend!
I have seborrheic keratosis on both sides of my face which has been disappearing with this product. I know this is not an expected outcome but I am beyond impressed. The dermatologist confirmed that my face was covered in SK and wanted to freeze some off. I wanted to wait and see what Active Pro Serum could do. Well, in 2 weeks SK has faded and made more than 50% disappear now I have used it for a few moths and it is at least 90% gone. Nothing else has ever worked for my SK. This product does work on SK and you have liquid gold.
I’m not going to lie. It took a while for me to notice an improvement in my skin quality, but it is slowly crept in over the last few weeks and I’ve been using this since June. My skin looks smoother and glowy again, not quite the glass glow as in my 20s but more of when I was in my early 30s. Considering I’m in early menopause I’m surprised I even have that much of an improvement and it’s guaranteed to be this product as it’s the only thing I’ve added to my skin routine as I’m already on prescription retinol.
Love this product and use it every night.
So far, I’m loving my results! My skin looks brighter and firmer already. I’m excited to see what continued use of the Active Pro Serum, morning and night, does for the wrinkles on my forehead. I’ll definitely be back with an update in a few weeks!
Love the product and how it feels on the skin. I can feel it working without any irriation.
Great product. 3 pack is great for daily use and one to keep in my travel bag
I can truly see a difference in my skin with this product!
I’ve been using the active pro serum for a couple of months now and really love the way it makes my skin look.
Ive read about this product for some time but when I found out I could get the generic in this product I immediately ordered. My skin started feeling a little firmer I used it five wks and I'm ordering my second bottle in hopes to see firmer skin in the future as well.
I am so glad I found Skincare Generics Active Pro Serum! I did a side-by-side test for one month and the results for the Skincare Generics were the same (if not better) in terms of tightening & firming my sagging jaw line. I also saw noticeable improvement in the wrinkles on BOTH sides of my face and around BOTH eyes. I actually believe the SG slightly outperformed the more expensive product in terms of hyperpigmentation and i love the application. I highly recommend this product and will continue to purchase! Plus their customer service is phenomenal. I asked a clinical question and they got back to me within 24 hours! Phenomenal!! Thank you so much!
Too soon to tell. I have only used it for three weeks and I have very sensitive skin and I have not had any reactions. I am hoping that it will help my neck firmness.
Very nice serum, soaks in very well. I have only used it for a couple of weeks, so I can't speak to the effectiveness. I have never used the name brand because of the cost, so I cannot do a comparison.
Im only one week in but ive used skinmedica before and although I liked it, the skincare generics active pro serum works even better. Its easy to use. Its light weight. I already bought 2 more. I will be back too.
Just got this and have been using the Skinmedica TNS for years. This feels, smells and looks EXACTLY the same. It's crazy. I even double checked the ingredients and they're the same. Not sure how they're getting away with this, lol. I'II report back once I've used it for a few weeks!
I can see firmness in my skin. Love this product!!
So far so good. I can definitely feel the tightening. My skin feels great. Hopefully better and better each day.
I love this serum! It helps to keep me looking young!!
Great product
Reviews reflect the personal opinions of customers and are not claims made by Skincare Generics. References to "dupes" or similarity are individual perceptions and do not imply product equivalence.
What exactly is ACTIVE PRO SERUM?
ACTIVE PRO SERUM is a growth factor–derived serum formulated to help improve the appearance of visible signs of aging skin, including fine lines and wrinkles. It features a dual-chamber pump with complementary blends, advanced growth factors, peptides, antioxidants, botanicals marine extracts, and skin-boosting nutrients to improve the appearance of skin texture and overall radiance.
ACTIVE PRO SERUM contains human fibroblast conditioned media sourced from a leading, FDA-registered, U.S. biotechnology manufacturer that produces cell-derived ingredients used across biotechnology and premium skincare applications. The conditioned media is derived from ethically donated, postpartum umbilical tissue and produced in compliance with U.S. regulatory standards.
Packaged in a dual-chamber pump dispenser:
Chamber 1: Advanced blend of growth factor and peptide ingredients designed to help address visible signs of aging.
Chamber 2: Combination of botanicals and marine extracts to support skin renewal and resilience.
• SkinSkool - Match Excellence Reward 2026
What ingredients are in ACTIVE PRO SERUM?
Aqua/Water/Eau, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin
Our Human Fibroblast Conditioned Media is sourced from a U.S. based biotechnology partner that specializes in human cell culture and regenerative research technologies. The conditioned media is derived from human fibroblast stem cells originally sourced from ethically obtained umbilical tissue that is voluntarily donated postpartum and not derived from aborted fetal tissue.
It is naturally rich in extracellular vesicles (including exosomes), growth factors, and signaling proteins that support skin renewal and cellular communication. Our conditioned media contains naturally occurring extracellular vesicles in the 60–90 nm range at concentrations on the order of approximately 10¹² to 10¹³ (1 to 10 trillion) particles per milliliter, making it a robust source of bioactive components for cosmetic formulations.
Our conditioned media has undergone comprehensive evaluation for cosmetic use and was selected based on stringent quality, safety, and performance benchmarks. We maintain strict standards for ethical sourcing and scientific validation.
Is ACTIVE PRO SERUM exactly the same as the competitor listed on the packaging?
Our product is not the same as the competitor. However, our formulations are developed by reviewing publicly available ingredient lists and selecting similar categories of ingredients where appropriate. Each product is independently formulated and manufactured.
Our products are also formulated with careful attention to texture and sensory experience. More importantly, we are always looking to improve upon our current formulations to deliver a luxury skincare experience.
Products are not affiliated with, endorsed by, or identical to any luxury brand.
How do the ingredients in ACTIVE PRO SERUM match with the competitor?
Each Skincare Generics product is independently formulated using similar categories of ingredients where appropriate. Ingredient comparisons are based solely on publicly available information and do not reflect formulation equivalence, performance equivalence, or clinical similarity.
For transparency, consumers may review publicly available ingredient lists on brand websites to compare ingredients.
How does the price of ACTIVE PRO SERUM compare with the competitor?
You can view a side-by-side, comparison of ACTIVE PRO SERUM's price vs. our competitor's price under the "Compare Prices" tab in the product description section.
How do "dupe" websites such as SkinSkool and SkinSort rate ACTIVE PRO SERUM vs. the competitor?
Here is ACTIVE PRO SERUM's rating on the different "dupe" websites:
• SkinSkool’s #1 Rated Match
• SkinSort’s #1 Rated Dupe
Ratings and terminology used by third-party websites reflect their independent criteria and do not imply equivalence.
Are there any published articles about ACTIVE PRO SERUM?
• SkinSkool - A New Serum Launch That Mirrors SkinMedica’s TNS Advanced+ At 83% Less
Editorial and comparative language, product classifications, and descriptions in third-party articles reflect the authors’ independent opinions and do not imply equivalence.
Are your skincare products considered clean?
While there is no industry-wide definition for “clean beauty,” major retailers such as Sephora and Ulta have established their own standards and guidelines. These typically involve excluding certain ingredients considered potentially harmful or questionable, such as sulfates, parabens, phthalates, and synthetic fragrances.
As we review publicly available ingredient lists when developing our products, some formulations may align with certain retailer “clean” standards, while others may contain ingredients that fall outside these guidelines, such as fragrance.
We encourage you to review each ingredient list individually to determine what aligns with your personal preferences and definition of “clean.”
How long will it take to receive my order?
It takes 1 - 2 business days to fulfill your order. Orders placed by 12pm CT, Monday through Friday, ship the same day. Orders received after the cutoff or on weekends will be processed the following business day.
Is international shipping available?
No, Skincare Generics does not currently offer direct international shipping.
Some customers choose to use third-party package forwarding services that provide a U.S. shipping address and then forward the package internationally, such as MyUS, Shipito, Stackry, Planet Express, and forward2me. These services are independent third parties and are not affiliated with or endorsed by Skincare Generics.
Once an order is delivered to the U.S. address entered at checkout, Skincare Generics is no longer responsible for the shipment or for any issues that arise afterward, including delays, loss, damage, customs issues, duties, taxes, fees, or forwarding errors. Refunds, replacements, and other remedies under our policies do not apply to issues arising after delivery to the forwarding address.
How do I manage or edit my subscription (delivery frequency, items, address, etc.)?
Here's how to log into your account and edit or manage your subscription (delivery frequency, items, address, etc.):
1) Log into your account
On Desktop (computer)
On Mobile (phone)
2) Change your subscription delivery frequency
If you don't see the "Frequency / Schedule" option
Sometimes certain settings don't allow self-service frequency changes. If you don't see that option, contact support at skincaregenerics.com/pages/contact and include:
...and we'll help update it for you.
What is your return policy?
We have a 30-day return no questions asked return policy, which means you have 30 days after receiving your item to request a return for any reason. Just email Customer Support and we will initiate a return or exchange.
Overall rating: 4.8 / 5 from 623 reviews.
I am a long time Skinmedica TNS user. I bought this while I still had TNS left to do a morning / evening rotation between the two. It feels the same, has the same consistency and I truly can't tell the difference. The one concern has been I've struggled a bit with the pump, but that has since been re-designed since I last purchased. I will most definitely be a return customer, in fact, I'm back now to purchase more!
I literally can’t tell the difference in results with Active Pro Serum versus SkinMedica TNS advanced serum! This product is so much more affordable and less product waste! So glad I discovered it! ❤️🙌🏽
I have been a loyal customer of the skinmedica TNS serum for 3 years. I was looking for something that would not be so bulky when traveling due to packaging. Happened to find the generic version and was pleasently suprised with the quality. Generic product is 75% cheaper. No going back
The Skincare generic brand is very similar to the Skinmedica TNS serum. I really enjoy using it.
Ingredients are exactly the same, the order of ingredients are exactly the same, the smell is exactly the same, and as you can see on the video the texture, color, and appearance is exactly the same as Skinmedica TNS. I’ll be buying this product from now on.
I absolutely love this product. I love it when you guys throw a little discount and I just want to stock up. I don’t want to run out amazing product same exact results like I’m just so happy to be able to get this at a more economical price than the Skin Medica TNS.
I have been using this for about a month now. I also have the TNS and was using that before. I know my skin is moisturized just as well as the TNS and it feels the same on my skin. I have been using it twice a day, but since it’s only been a month I’m not expecting amazing results yet. I plan on using this for at least 6 months to see results. I have deep forehead lines and a crease between my eyes I’d like to see some improvement on. Also wrinkles and darkness under my eyes, basically the difficult areas to see results from. I like the texture a lot, I love that it’s fragrance free as well. I’m purchasing a 3 pack as soon as I finish this review.
I’m 38 and had been using the TNS serum for about a year and it made the best difference in my skin. I recently heard about this one and I can tell no difference between it and the expensive one. This one smells and feels the same with the same great results. Keeps my skin feeling firm and looking glowy. I have extremely sensitive and reactive skin and no issues here! SO glad there is a MUCH more affordable option
Actual TNS user here. Tried this and I’m honestly impressed. Feels amazing on my skin and absorbs real well. I actually like that it smells like the original. Great product for the price
The photo I enclosed is a closeup of an area that is problematic for many women my age (closing in on 74 in the fall). I get many comments (even from the PA at my dermatologist) about how good my skin looks (I know they kindly keep “for your age” to themselves). I’ve used the original SkinMedica TNS product for many years but often take a break due to cost. It’s early, but the Active Pro Serum formula seems to behave identically to the TNS. Would love to see Skincare Generics up the formula to include Exosomes, which SkinMedica has not done…yet. In the meantime this is a winner!
My current active serum costs me $140. And I don't use a vitamin C because it bothers my skin. This active serum is a fraction of the cost and no joke, I see results in 2 weeks of using it! And this vitamin C has not bothered my skin whatsoever! Definitely ordering again and have already recommended to friends.
After getting through two bottles of the Active Pro Serum my skin has never felt better. This is my new go to!! I’m so happy to get this for such a good price. I’m trying all your products next!
Absolutely love this and will be purchasing it again!!!!
Great product! I’m on my 4th bottle. Great customer service as well. Thank you!
It’s great
Love! Just like the tns! I’ve use the other in the past and can say that it smells and feels the exact same. I feel like results are the same too. Purchasing my second bottle.
Absolutely addicted - top quality, fabulous price. My skin jadores it 💖
I used the TNS serum for several months , loved the product but could non longer afford it. I tried this Active Pro-Serum from Skincare Generics and I can honestly say it is identical and has continued to do wonders for my skin!
Great! Wonderful product
I love this product! It does wonders for my skin!
Love the products. Feels, performs and smells like the "original" music higher priced versions. Glad I found these products
Skincare Generics is a wonderful company. Their products are moisturizing and feel great on my skin! I would highly recommend!
I have seborrheic keratosis on both sides of my face which has been disappearing with this product. I know this is not an expected outcome but I am beyond impressed. The dermatologist confirmed that my face was covered in SK and wanted to freeze some off. I wanted to wait and see what Active Pro Serum could do. Well, in 2 weeks SK has faded and made more than 50% disappear now I have used it for a few moths and it is at least 90% gone. Nothing else has ever worked for my SK. This product does work on SK and you have liquid gold.
I’m not going to lie. It took a while for me to notice an improvement in my skin quality, but it is slowly crept in over the last few weeks and I’ve been using this since June. My skin looks smoother and glowy again, not quite the glass glow as in my 20s but more of when I was in my early 30s. Considering I’m in early menopause I’m surprised I even have that much of an improvement and it’s guaranteed to be this product as it’s the only thing I’ve added to my skin routine as I’m already on prescription retinol.
Love this product and use it every night.
So far, I’m loving my results! My skin looks brighter and firmer already. I’m excited to see what continued use of the Active Pro Serum, morning and night, does for the wrinkles on my forehead. I’ll definitely be back with an update in a few weeks!
Love the product and how it feels on the skin. I can feel it working without any irriation.
Great product. 3 pack is great for daily use and one to keep in my travel bag
I can truly see a difference in my skin with this product!
I’ve been using the active pro serum for a couple of months now and really love the way it makes my skin look.
Ive read about this product for some time but when I found out I could get the generic in this product I immediately ordered. My skin started feeling a little firmer I used it five wks and I'm ordering my second bottle in hopes to see firmer skin in the future as well.
I am so glad I found Skincare Generics Active Pro Serum! I did a side-by-side test for one month and the results for the Skincare Generics were the same (if not better) in terms of tightening & firming my sagging jaw line. I also saw noticeable improvement in the wrinkles on BOTH sides of my face and around BOTH eyes. I actually believe the SG slightly outperformed the more expensive product in terms of hyperpigmentation and i love the application. I highly recommend this product and will continue to purchase! Plus their customer service is phenomenal. I asked a clinical question and they got back to me within 24 hours! Phenomenal!! Thank you so much!
Too soon to tell. I have only used it for three weeks and I have very sensitive skin and I have not had any reactions. I am hoping that it will help my neck firmness.
Very nice serum, soaks in very well. I have only used it for a couple of weeks, so I can't speak to the effectiveness. I have never used the name brand because of the cost, so I cannot do a comparison.
Im only one week in but ive used skinmedica before and although I liked it, the skincare generics active pro serum works even better. Its easy to use. Its light weight. I already bought 2 more. I will be back too.
Just got this and have been using the Skinmedica TNS for years. This feels, smells and looks EXACTLY the same. It's crazy. I even double checked the ingredients and they're the same. Not sure how they're getting away with this, lol. I'II report back once I've used it for a few weeks!
I can see firmness in my skin. Love this product!!
So far so good. I can definitely feel the tightening. My skin feels great. Hopefully better and better each day.
I love this serum! It helps to keep me looking young!!
Great product
